Robert M Brosh Selected Research

DNA Helicases

1/2022	RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1.
1/2022	WRN rescues replication forks compromised by a BRCA2 deficiency: Predictions for how inhibition of a helicase that suppresses premature aging tilts the balance to fork demise and chromosomal instability in cancer.
1/2021	Synthetic Lethal Interactions of RECQ Helicases.
12/2020	DNA helicases and their roles in cancer.
10/2020	Repeat expansions confer WRN dependence in microsatellite-unstable cancers.
1/2019	G4-Interacting DNA Helicases and Polymerases: Potential Therapeutic Targets.
1/2019	A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN).
1/2018	BLM's balancing act and the involvement of FANCJ in DNA repair.
1/2018	New Insights Into DNA Helicases as Druggable Targets for Cancer Therapy.
1/2018	RecQ and Fe-S helicases have unique roles in DNA metabolism dictated by their unwinding directionality, substrate specificity, and protein interactions.

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Robert M Brosh Research Topics

Disease

39	Neoplasms (Cancer) 01/2022 - 05/2005
30	Genomic Instability 01/2022 - 04/2002
16	Chromosomal Instability (Chromosome Stability) 11/2021 - 09/2006
15	Werner Syndrome (Werner's Syndrome) 01/2022 - 04/2002
13	Premature Aging 01/2022 - 08/2004
13	Fanconi Anemia (Fanconi's Anemia) 09/2021 - 11/2010
11	Inborn Genetic Diseases (Disease, Hereditary) 01/2020 - 02/2003
11	Bloom Syndrome 01/2018 - 06/2002
8	Breast Neoplasms (Breast Cancer) 11/2015 - 07/2005
7	Cockayne Syndrome (Syndrome, Cockayne) 01/2019 - 02/2002
4	Carcinogenesis 01/2014 - 01/2006
3	Rothmund-Thomson Syndrome (Syndrome, Rothmund-Thomson) 04/2013 - 07/2005
2	Ovarian Neoplasms (Ovarian Cancer) 01/2018 - 01/2014
2	Mitochondrial Diseases (Mitochondrial Disease) 11/2016 - 07/2016
2	Chromosome Breakage 07/2014 - 01/2013
2	Xeroderma Pigmentosum (Kaposi's Disease) 01/2014 - 09/2013
2	Bone Marrow Failure Disorders 01/2014 - 09/2013
1	Ichthyosis (Xeroderma) 01/2022
1	Microsatellite Instability 10/2020
1	Neuroblastoma 11/2016
1	Renal Cell Carcinoma (Grawitz Tumor) 10/2014
1	Disease Progression 01/2014
1	DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes) 10/2013
1	Dyskeratosis Congenita (X-Linked Dyskeratosis Congenita) 09/2013
1	Chromosome Aberrations (Chromosome Abnormalities) 09/2013
1	Ataxia Telangiectasia (Louis Bar Syndrome) 09/2013
1	Craniosynostosis radial aplasia syndrome 04/2013
1	Microcephaly 01/2013
1	Hypersensitivity (Allergy) 05/2009
1	Aneuploidy (Aneuploid) 04/2008
1	Sensorineural Hearing Loss 02/2003
1	Dwarfism 02/2003

Drug/Important Bio-Agent (IBA)

37	DNA (Deoxyribonucleic Acid)IBA 09/2021 - 10/2002
29	Proteins (Proteins, Gene)FDA Link 09/2021 - 04/2002
27	DNA HelicasesIBA 01/2022 - 08/2004
18	RecQ HelicasesIBA 11/2015 - 01/2004
9	A-Form DNA (A-DNA)IBA 09/2021 - 10/2002
7	EnzymesIBA 01/2018 - 01/2005
6	Exonucleases (3' 5' Exonuclease)IBA 01/2022 - 10/2002
4	Nucleic AcidsIBA 01/2020 - 01/2007
4	SulfurIBA 01/2018 - 01/2013
4	IronIBA 01/2018 - 01/2013
4	Mitomycin (Mitomycin-C)FDA LinkGeneric 07/2014 - 01/2013
3	Biomarkers (Surrogate Marker)IBA 10/2020 - 01/2014
3	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 01/2019 - 01/2006
3	Replication Protein AIBA 01/2019 - 08/2005
3	Flap EndonucleasesIBA 01/2005 - 10/2002
2	ChromatinIBA 11/2021 - 04/2008
2	Ribosomal DNA (rDNA)IBA 01/2021 - 11/2016
2	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2018 - 01/2011
2	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 11/2016 - 01/2011
2	Mitochondrial DNA (mtDNA)IBA 07/2016 - 10/2014
2	DNA-Binding Proteins (DNA Binding Protein)IBA 07/2014 - 08/2005
2	Pharmaceutical PreparationsIBA 10/2013 - 05/2005
2	NSC 617145IBA 10/2013 - 09/2013
2	Werner Syndrome HelicaseIBA 09/2013 - 01/2011
2	Bloom syndrome proteinIBA 02/2011 - 03/2004
2	Telomerase (Telomerase Reverse Transcriptase)IBA 06/2006 - 05/2005
1	ZincIBA 01/2022
1	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 01/2019
1	CamptothecinIBA 01/2019
1	Single-Stranded DNA (DNA, Single Stranded)IBA 01/2019
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 01/2019
1	Cruciform DNA (Holliday Junctions)IBA 01/2019
1	Fanconi Anemia Complementation Group ProteinsIBA 01/2019
1	Mutant Proteins (Protein, Mutant)IBA 01/2018
1	B-Form DNA (B-DNA)IBA 11/2016
1	Untranslated RNA (Noncoding RNA)IBA 01/2016
1	Long Noncoding RNAIBA 01/2016
1	Ligases (Synthetase)IBA 04/2015
1	RNA (Ribonucleic Acid)IBA 04/2015
1	UbiquitinIBA 04/2015
1	DNA-Activated Protein KinaseIBA 09/2013
1	maleimideIBA 01/2011
1	1-(propoxymethyl)maleimideIBA 01/2011
1	telomestatinIBA 01/2011
1	GuanineIBA 06/2008
1	triplex DNA (H-DNA)IBA 05/2008
1	Biological ProductsIBA 12/2007
1	DeoxyguanosineIBA 03/2006
1	2'-deoxyadenosineIBA 03/2006
1	Small Interfering RNA (siRNA)IBA 05/2005
1	EndonucleasesIBA 03/2004
1	Staphylococcal Protein A (Protein A)IBA 03/2004
1	human EXO1 proteinIBA 06/2003
1	Retinaldehyde (Retinal)IBA 02/2003
1	8-hydroxyguanineIBA 02/2002
1	Adenosine Triphosphatases (ATPase)IBA 02/2002

Therapy/Procedure

13	Therapeutics 01/2022 - 05/2005
5	Drug Therapy (Chemotherapy) 01/2018 - 01/2007
1	Radiotherapy 04/2009